Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden
  • Author : David E. Lewis
  • Release Date : 15 June 2021
  • Publisher : Elsevier
  • Genre : Medical
  • Pages : 260
  • ISBN 13 : 0128210273

Download or read book entitled Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden written by David E. Lewis and published by Elsevier online. This book was released on 15 June 2021 with total pages 260. Available in PDF, EPUB and Kindle. Book excerpt: Addition, elimination and substitution are foundational reactions in organic chemistry. Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses the major protagonists in these reactions and their major contributions to synthesis. It provides an overview of the history of these reactions. Hofmann, Zaitsev, and Markovnikov are introduced with a biography detailing their major discoveries and contributions to organic chemistry. The history of the controversies around Markovnikov's Rule are addressed, and the author will provide his perspective on the question. The book introduces Walden's original demonstration of configuration inversion, discusses bimolecular elimination reactions, regioselective addition reactions and regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus and comprehensive coverage, this book belongs on the shelf of every organic chemist. Introduces Markovnikov, Zaitsev, Hofmann and Walden as actual persons, rather than just an abstract term used as a form of short-hand to describe the rules Discusses, in depth, the discovery and usage of these reactions and rules since their discovery to their most recent applications Includes biographical materials about chemists responsible for major changes in the application of the rules Traces the history of the applications of these reactions (e.g., anti-Markovnikov additions in catalytic organic synthesis, and reactions such as the Mitsunobu reaction improving the original SN2 displacement)